A Review of Exercise Training Combined with VItamin D Supplementation Alleviates Muscle Atrophy
Qin, Yihua
Qin, Yihua
Abstract
Muscle atrophy is a disease characterized by a decrease in skeletal muscle mass and strength. In recent years, with the aggravation of population aging and the increase of type 2 diabetes, the incidence rate of muscle atrophy has increased year by year. The occurrence of muscle atrophy can be caused by various factors, such as nerve damage, chronic inflammation, metabolic disorders, etc., which seriously reduces the quality of life of the elderly population and chronic disease patients. As a fat soluble hormone, vitamin D not only plays a crucial role in maintaining bone health, but also plays an important role in regulating muscle function and improving muscle atrophy. After being activated by the liver and kidneys in the body, vitamin D binds to the vitamin D receptor (VDR) to regulate muscle protein synthesis and muscle cell energy metabolism. Research has found that patients with muscle atrophy often suffer from vitamin D deficiency and decreased VDR expression, which may be related to a decline in muscle function. In recent years, studies have shown that supplementing with vitamin D can improve muscle atrophy. Exercise training is considered a crucial intervention for improving muscle atrophy. Studies have found that exercise can upregulate the expression of the vitamin D receptor (VDR) in skeletal muscle, which may be a potential mechanism by which exercise ameliorates muscle atrophy. However, the underlying mechanisms through which exercise training combined with vitamin D supplementation may enhance the amelioration of muscle atrophy remain incompletely elucidated. Therefore, this article systematically reviews the literature on the effects of exercise training combined with vitamin D supplementation on muscle atrophy, particularly focusing on the elderly and patients with type 2 diabetes. This review aims to summarize the progress of research in this area and provide a reference for future studies.
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Date
2024-09-20
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University of Wyoming Libraries
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Keywords
muscle atrophy,exercise training,vitamin D supplement