Two-Year Serosurvey of a Rural Population for West Nile Virus IgG and IgM Antibodies, A

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dc.contributor.authorLamb, Rachel
dc.contributor.authorGraham, Tyler
dc.contributor.authorGoff, Russell
dc.contributor.authorShearer, Shelby
dc.contributor.authorHutchison, Tetiana
dc.contributor.authorPrintz, Roderick
dc.contributor.authorNiemeyer, Kelli
dc.contributor.authorGraham, Josh
dc.contributor.authorHosking, Seth
dc.contributor.authorMcAllister, Steven
dc.contributor.authorSeville, Scott
dc.date.accessioned2024-03-14T13:53:03Z
dc.date.available2024-03-14T13:53:03Z
dc.descriptionBackground and Objective: West Nile Virus (WNV) is an RNA arbovirus in the family Flaviviridae. Most human infections are asymptomatic with less than one percent of patients exhibiting severe symptoms including encephalitis, paralysis, and death. To test the hypothesis that the recent decline in WNV cases in Fremont County is correlated to widespread exposure, serosurveys were conducted for two years. Methods: Serum samples were drawn and tested for the presence of WNV IgG and IgM antibodies using Enzyme Linked Immunosorbant Assays. The presence of high titers of IgG antibodies is indicative of past exposures; IgM indicates more recent exposure. Results: In 2011, of 85 subjects 16.5% (95% CI: 8.9%-24.1%) were positive for IgG and 9.4% (95% CI: 3.2%-15.6%) were for IgM. In 2012, 95 subjects were tested. 10.5% (95% CI: 4.34%-16.66%) were positive for IgG and 5.3% (95% CI: 0.8%- 9.8%) for IgM. Discussions and Conclusions: These results indicate that most residents of Fremont County have been exposed to WNV and the recent decline in cases is not correlated to widespread exposure.
dc.description.sponsorshipThis research was supported by a grant from the National Center for Research Resources (5P20RR016474-12) and the National Institute of General Medical Sciences (8 P20 GM103432-12) divisions of the National Institutes of Health.
dc.identifier.doi10.15786/13703194
dc.identifier.urihttps://wyoscholar.uwyo.edu/handle/internal/7483
dc.identifier.urihttps://doi.org/10.15786/13703194
dc.languageEnglish
dc.language.isoeng
dc.publisherUniversity of Wyoming Libraries
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleTwo-Year Serosurvey of a Rural Population for West Nile Virus IgG and IgM Antibodies, A
dc.typepresentation
dspace.entity.typePublication
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