Type 3 Diabetes: A comparative molecular analysis of the origins of this new disease
thesisposted on 13.12.2019, 00:00 authored by Colter Voss
Type 3 diabetes is a new characterization of Alzheimer disease. The purpose of this comparative analysis is to outline and juxtapose Type 1 and Type 2 diabetes mellitus and Type 3 diabetes. This comparative analysis is based on published literature regarding both Type 1 and Type 2 diabetes mellitus, as well as literature on glucose metabolism and regulation, in addition to the literature on Type 3 diabetes and Alzheimer disease. This analysis includes a brief description and introduction to the history of diabetes, along with molecular descriptions and demonstrations of glucose metabolism and regulation. The regulation of gene expression, signaling, and mechanisms of action were investigated and demonstrated for both insulin and glucagon. Type 1 diabetes mellitus and Type 2 were discussed to the extent of manifestation of symptoms, molecular basis of the disease and pathophysiology of each type. Type 3 diabetes is also presented, including the molecular basis of the disease and the pathophysiology. Molecular mechanisms were compared and analyzed between both Type 1 and Type 2 diabetes mellitus and Type 3 diabetes. This paper reviews the evidence supporting the hypothesis that one form of Type 3 diabetes is related to Alzheimer disease, based on the molecular and clinical similarities between the mechanisms of vascular damage, insulin resistance, and formation of amyloid plaques contributing to the pathophysiology of both disorders.