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TDP-43 Knock Out and Neuronal Death in a Mouse Model of Frontotemporal Dementia

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thesis
posted on 21.05.2021, 20:42 by Amanda Lyn Jane Johnston
Frontotemporal dementia (FTD) is a group of neurodegenerative diseases involving loss of neurons in the frontal and temporal lobes leading to changes in personality, behavior, and language and is the second most common cause of dementia in those age 65 years or younger after Alzheimer's Disease. The most common form of FTD arises out of aggregation of the protein TDP-43; however, the exact pathogenic mechanism is not known. This study attempts to investigate one of the two main proposed mechanisms using a mouse model of FTD by replicating clearance of TDP-43 from neuronal nuclei with genetic editing utilizing the Cre/LoxP system delivered by a virus. Results from this study show promise for future research and therapeutic and medicinal interventions.

History

Advisor

Li, Yun

Country

United States

Degree

Bachelor's

Graduation date

15/05/2021

Language

English

Subject

Neuroscience