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Effects of Bisphenol A (BPA) on the Neural Development of the Xenopus laevis Tadpole, The

thesis
posted on 02.01.2017, 00:00 by Mark A. Merlino
Bisphenol A (BPA) has been used as an additive in plastics as well as food storage cans. Concerns over the possible effects of BPA have caused many companies to avoid using the chemical. Here, we study the effect of BPA on the neural development of the Xenopus laevis tadpole, specifically the development of the visual system. For this study, tadpoles are reared in varying concentrations of BPA, and then visual system function is assessed at the behavioral, circuit, and single cell level. Our preliminary results suggest that sub-lethal concentrations of BPA significantly impact visual avoidance behavior. This behavioral deficit could be due to the observed decrease in synaptic activity. Additional experiments will be carried out to further characterize this decrease.

History

Advisor

Pratt, Kara

ISO

eng

Language

English

Publisher

University of Wyoming. Libraries

Collection

Honors Theses AY 17/18