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Chondroitin Sulfate Proteoglycan Modulation as a Potential Therapy for Traumatic Injury to the Central Nervous System
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posted on 2020-05-11, 00:00 authored by Maximilian RosenfeldCompared to the peripheral nervous system (PNS), the central nervous system (CNS) is limited
in its ability to regenerate, resulting in chronic deficits that are difficult to treat. Elements of mild
plasticity that contribute to functional recovery are observed after injury. Therefore, strategies to
enhance plasticity after injury to promote repair and regeneration are key, and this can be
accomplished through the modulation of the extracellular matrix (ECM) in the brain and spinal
cord. One such strategy utilizes the bacterial enzyme chondroitinase ABC (ChABC) to degrade
inhibitory chondroitin sulfate proteoglycans (CSPGs) to produce a growth permissive
environment for neurons and their regenerating axons. This review will discuss the pathology
behind CNS injury, the role of CSPGs as inhibitors, and the efficacy of modulating CSPGs to
promote restorative plasticity and functional recovery after CNS injury.