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Tauroursodeoxycholic Acid Alleviates High-Fat Diet-Induced Cardiomyocyte Contractile Dysfunction

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posted on 21.07.2014, 00:00 by Kacy Richmond
Background: Obesity is an independent risk factor for cardiovascular disease. In this study, we observed the effects of tauroursodeoxycholic acid (TUDCA), a known endoplasmic reticulum stress (ER stress) inhibitor, on high-fat diet-induced cardiomyocyte contractile dysfunction in mice. Methods: 3- to 4-month-old C57 mice were fed a low- or high-fat for 20 weeks. High fat-fed mice were subdivided into 2 groups and treated either with TUDCA (300mg/kg.bw.day-1) or natural saline for 15 days prior to the assessment of contractile parameters of isolated ventricular cardiomyocytes including peak cell shortening (PS), time-to-PS (TPS), time-to-90% re-lengthening (TR90) and maximal velocities of shortening and re-lengthening (±dL/dt). Results: High-fat diet depressed PS, ±dL/dt and TR90 compared to the low-fat diet. Interestingly, TUDCA treatment alleviated the depression of PS and ±dL/dt but not TR90. Conclusion: TUDCA may have potential therapeutic implications in treating obesity-induced cardiac dysfunction via a mechanism involving reduced ER stress in the cardiomyocytes, which warrants further studies.

History

Advisor

Turdi, Subat Ren, Jun

ISO

eng

Language

English

Publisher

University of Wyoming. Libraries

Usage metrics

UGRD 2010

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Exports