University of Wyoming
Browse
UGRD_2010_Spring_Smith_Jennifer.pdf (921.52 kB)
Download file

Effect of the GnRH Agonist, Deslorelin, on the Prolactin Axis

Download (921.52 kB)
presentation
posted on 2021-11-15, 18:42 authored by Jennifer Smith
Gonadotropin-releasing hormone (GnRH) agonists have become increasingly important as anti-fertility agents in the veterinary field over the past decade, proving a successful alternative to surgical sterilization in domestic and captive animals. Although previous GnRH agonists used in reproductive management demonstrated several shortcomings, deslorelin, a relatively new GnRH agonist, has overcome many of these problems and has successfully suppressed reproduction in numerous species, including domestic dogs, cats, wild canids, felids and cattle. Approximately 135-day old Sprague-Dawley rats were used. Animals received 1 of 2 treatments for 6 weeks: a 1.1mg deslorelin implant alone or a sham implant insertion. Both the percentage of prolactin cells and the total number of cells differed insignificantly between treatment groups (P>0.05). These results disagree with our hypothesis that the known decrease in FSH-immunoreactive cells during treatment would affect the lactotrope population. It is possible, however, that lactotropes depend on LH rather than FSH cells. Thus, further research into the relationship between lactotropes and gonadotropes during treatment with GnRH agonists is required.

History

Advisor

Skinner, Donal

ISO

eng

Language

English

Publisher

University of Wyoming. Libraries

Department

  • Library Sciences - LIBS

Usage metrics

    Keywords

    Licence

    Exports